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TEPP-46 (ML-265) is a potent and selective PKM2 activator. TEPP-46 activates tumor-specific PKM2 (EC₅₀ = 92 nM) by binding to the dimer-dimer interface between two subunits of PKM2 and inducing tetramerisation, which is the most active form of the enzyme. In mice with A549 xenograft tumors, ML-265 displays good oral bioavailability with relatively low clearance, long half-life.
Product Type:
Biochemicals
CAS Number:
1221186-53-3
Storage Temp:
-20°C
Compound Purity:
≥98% by HPLC
Molecular Weight:
372.5
UNSPSC Code:
12352200
