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TEPP-46

Supplier:
Catalogue number:
B2164-5
Size:
5 mg
Product is available in:
  • UK
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  • Rest of World
£377.00 Estimated delivery Wed 28 Apr
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TEPP-46 (ML-265) is a potent and selective PKM2 activator. TEPP-46 activates tumor-specific PKM2 (EC₅₀ = 92 nM) by binding to the dimer-dimer interface between two subunits of PKM2 and inducing tetramerisation, which is the most active form of the enzyme. In mice with A549 xenograft tumors, ML-265 displays good oral bioavailability with relatively low clearance, long half-life.

Product Type:

Biochemicals

CAS Number:

1221186-53-3

Storage Temp:

-20°C

Compound Purity:

≥98% by HPLC

Molecular Weight:

372.5

UNSPSC Code:

12352200

TEPP-46

TEPP-46