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DASA-58 is a selective activator of pyruvate kinase M2 (PKM2) (AC₅₀ = 38 nM). DASA-58 converts PKM2 to a constitutively active enzyme state that is resistant to inhibition by tyrosine-phosphorylated protein. In cancer, the altered glucose metabolism can be influenced by the regulatory properties of PKM2.
Product Type:
Biochemicals
CAS Number:
1203494-49-8
Storage Temp:
-20°C
Compound Purity:
≥98% by HPLC
Molecular Weight:
453.53
UNSPSC Code:
12352200
