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CX-5461 is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC₅₀s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC₅₀ ≥25 µM). At 50 mg/kg, CX-5461 demonstrates in vivo antitumor activity against human solid tumors in mouse xenograft models.
Product Type:
Biochemicals
CAS Number:
1138549-36-6
Storage Temp:
-20°C
Compound Purity:
≥98% by HPLC
Molecular Weight:
513.61
UNSPSC Code:
12352200
