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CX-5461

Supplier:
Catalogue number:
B2183-5
Size:
5 mg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£377.00 Estimated delivery Wed 28 Apr
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CX-5461 is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC₅₀s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC₅₀ ≥25 µM). At 50 mg/kg, CX-5461 demonstrates in vivo antitumor activity against human solid tumors in mouse xenograft models.

Product Type:

Biochemicals

CAS Number:

1138549-36-6

Storage Temp:

-20°C

Compound Purity:

≥98% by HPLC

Molecular Weight:

513.61

UNSPSC Code:

12352200

CX-5461

CX-5461