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Glycine-β-muricholic Acid

Supplier:
Catalogue number:
CAY9003230-1 mg
Size:
1 mg
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An intestine-selective FXR antagonist; glycine-conjugated form of β-muricholic acid; inhibits chenodeoxycholic acid- and GW 4064-induced expression of the FXR target genes Shp and Fgf15 at 100 µM; resistant to hydrolysis by fecal BSH isolated from gut microbiota; decreases Shp and Fgf15 mRNA expression in ileum, but not liver, and reduces ceramide levels and expression of various ceramide synthesis-related genes in ileum of mice with high-fat diet-induced obesity and db/db mice at 10 mg/kg; prevents weight gain, reduces blood glucose levels, and increases insulin sensitivity as well as prevents development of cholestasis and necrotic lesions in liver of mice with high-fat diet-induced obesity

Product Type:

Biochemicals

CAS Number:

66225-78-3

Alternative Names:

n-[(3α,5β,6β,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl]-glycine, gly-mca, gβmca

Storage Temp:

-20°C

Formulation:

A crystalline solid

Compound Purity:

≥95%

UNSPSC Code:

12352200

CAY9003230-1 mg: Glycine-β-muricholic Ac

CAY9003230-1 mg: Glycine-β-muricholic Acid