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464930-42-5
≥95%
A crystalline solid
793.4
(3r)-3-(1,3-benzodioxol-5-yl)-n-[(6-methoxy-2-naphthalenyl)sulfonyl]-β-alanyl-4-[[(2r,6s)-2,6-dimethyl-1-piperidinyl]methyl]-n-methyl-n-(1-methylethyl)-d-phenylalaninamide, monohydrochloride
- Data sheet: View or download
- MSDS: View or download
A selective, non-peptide bradykinin B1 receptor antagonist (Kis = 0.48-0.73 and 358-481 nM for B1 and B2 receptors, respectively); inhibits the contraction of rabbit aorta and rat ileum induced by des-Arg9-BK ex vivo; reduces tissue damage and neutrophil accumulation in a rat model of splanchnic artery occlusion/reperfusion-induced intestinal injury; inhibits des-Arg9-BK-induced paw edema in mice at 3 and 10 mg/kg; reduces fibrosis in a unilateral ureteral obstruction mouse model of kidney fibrosis; reduces mean arterial blood pressure in two rat models of hypertension; reduces plasma glucose and insulin levels in a glucose-fed rat model of insulin resistance; exhibits analgesic properties in several rodent models of hyperalgesia
-20°C
