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20575-57-9
≥98%
A crystalline solid
284.3
7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4h-1-benzopyran-4-one
- Data sheet: View or download
- MSDS: View or download
An isoflavone with diverse biological activities; ER partial agonist that inhibits 17β-estradiol binding to ERα and ERβ (IC50s = 83.14 and 40.38 µM, respectively); induces tube formation by HUVECs in a Matrigel™ assay and angiogenesis in zebrafish; reduces growth of the poW and Dd2 strains of P. falciparum (IC50s = 4.2 and 9.8 µg/ml, respectively); selectively toxic for T. brucei brucei over Vero cells (IC50s = 12.7 and 159 µM, respectively); scavenges DPPH free radicals in a cell-free assay; inhibits xanthine/xanthine oxidase-induced toxicity in PC12 cells (EC50 = 50 ng/ml); reduces ALT and AST activity, triglyceride accumulation, and hepatic fibrosis in a mouse model of NASH at 12.5 and 25 mg/kg; decreases infarct volume and brain edema in a rat model of focal cerebral ischemia and reperfusion injury
-20°C
