Shipping is calculated in checkout
1219810-16-8
≥98%
A crystalline solid
440.9
(1s,3r)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1h-pyrido[3,4-b]indole-3-carboxylic acid, methyl ester
- Data sheet: View or download
- MSDS: View or download
A ferroptosis inducer; inhibits GPX4 in a context-dependent manner; inhibits GPX4 in the presence of cell cytosol or recombinant human 14-3-3ε but does not inhibit recombinant human selenocysteine-containing GPX4 or purified rat testis GPX4, at 100 µM; inhibits peroxidase activity in GPX4-overexpressing COH-BR1 breast cancer cell lysates at 50 nM; inhibits TrxR1 (IC50 = 7.9 µM in a cell-free assay); selectively cytotoxic to H-RasV12-expressing BJeLR cells over wild-type Ras-expressing BJeH cells (EC50s = 0.01 and 2 µM, respectively); induces lipid peroxidation in Pfa1 fibroblasts at 100 nM; prevents tumor formation and inhibits tumor growth in BJeLR mouse xenograft models at 100 mg/kg
-20°C
