£1188.00
Estimated delivery Wed 8 May
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
221529-58-4
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
309.4
Alternative Names:
4,5-dihydro-n-[4-[[4-(1-methylethoxy)phenyl]methyl]phenyl]-1h-imadazol-2-amine, ro 1138452
- Data sheet: View or download
- MSDS: View or download
Product Description:
An IP receptor antagonist; selective for the IP receptor over EP1, EP2, EP3, EP4, FP, and TP receptors and a panel of 30 other receptors and ion channels but does bind α2A-adrenergic and imidazoline I2 receptors; inhibits carbaprostacyclin-induced cAMP accumulation in SH-SY5Y cells (pKB = 8.8) and cicaprost-induced vasorelaxation of isolated human pulmonary arteries (pA2 = 8.2); decreases cicaprost-induced inhibition of platelet aggregation in human platelet-rich plasma; reduces acetic acid-induced writhing and carrageenan-induced paw hyperalgesia in rats (ED50s = 4 and 2.8 mg/kg, respectively)
Storage Temperature:
-20°C
