all-trans-4-hydroxy Retinoic Acid
Catalogue number:
CAY21378-1 mg
Supplier:
Size:
1 mg _$$_
Product is available in:
£497.00
Estimated delivery Fri 24 May
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
66592-72-1
Purity:
≥90%
Formulation:
A solid
Molecular Weight:
316.4
Alternative Names:
4-hydroxy-retinoic acid, 4-hydroxy ra, 4-oh-atra
- Data sheet: View or download
- MSDS: View or download
Product Description:
A metabolite of all-trans retinoic acid; formed through metabolism of all-trans retinoic acid by CYP26A1, B1, and C1; binds to RARs with a lower affinity than other all-trans retinoic acid metabolites (IC50s = 606, 298, and 892 nM for RARα, RARβ, and RARγ, respectively, in a radioligand binding assay); transactivates RARs with a lower efficacy than other metabolites (EC50s = 791, 64, and 94 nM for RARα, RARβ, and RARγ, respectively) but induces transcription of a reporter plasmid equipotently; inhibits cell growth, halts the cell cycle in the G1 phase, and induces differentiation of NB4 acute promyelocytic leukemia cells (EC50 = 79.8 nM)
Storage Temperature:
-80°C
