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ON-123300

Catalogue number:
CAY19902-5 mg
Supplier:
Size:
5 mg _$$_
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£209.00 Estimated delivery Wed 1 May
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:

1357470-29-1

Purity:

≥98%

Formulation:

A crystalline solid

Molecular Weight:

429.5

Alternative Names:

8-cyclopentyl-7,8-dihydro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-7-oxo-pyrido[2,3-d]pyrimidine-6-carbonitrile

Product Description:

A multi-kinase inhibitor; inhibits ARK5, Cdk4, and Cdk6 (IC50s = 3.87, 9.82, and 4.95 nM, respectively); inhibits FYN, PDGFRβ, Abl, and PI3Kδ (IC50s = 11.09, 26, 53.32, and 144 nM, respectively) among others; inhibits proliferation in a panel of 38 cancer cell lines (GI50s = 0.05-5 µM); also inhibits proliferation of U87 glioma cells (IC50 = 3.4 µM); reduces tumor growth in an MDA-MB-231 mouse xenograft model at 50 mg/kg every other day

Storage Temperature:

-20°C

CAY19902-5 mg: ON-123300
CAY19902-5 mg: ON-123300
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