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P505-15 hydrochloride

Supplier:
Catalogue number:
9583-25
Size:
25 mg
Product is available in:
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P505-15 is a potent, cell-permeable, highly selective, small molecule SYK inhibitor (IC₅₀ = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases. P505-15 blocks B cell receptor-mediated cell signaling and activation in whole blood (IC₅₀s = 0.27 and 0.28 µM, respectively), as well as Fcɛ receptor 1-mediated basophil degranulation (IC₅₀ = 0.15 µM).

Product Type:

Small Molecule Compounds

CAS Number:

1370261-97-4

Alternative Names:

2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide hydrochloride, PRT062607, PRT2607, BIIB-057

Storage Temp:

-20°C

Compound Purity:

≥98% by HPLC

Molecular Weight:

429.91

UNSPSC Code:

12352100

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