£153.00
Estimated delivery Tue 14 May
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
755037-03-7
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
482.8
Alternative Names:
4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-n-methyl-2-pyridinecarboxamide, bay 73-4506
- Data sheet: View or download
- MSDS: View or download
Product Description:
A multi-kinase inhibitor; inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ (IC50s = 1.5, 2.5, 4.2, 7, 13, and 22 nM, respectively); inhibits B-RAF, VEGFR3, FGFR, and Tie2 (IC50s = 28, 46, 202, and 311 nM, respectively); reduces tumor size in the MDA-MB-231 breast and 786-O renal cancer mouse xenograft models at 10 mg/kg; reduces tumor microvessel area and inhibits tumor growth in a panel of mouse xenograft models
Storage Temperature:
-20°C
