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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
65141-46-0
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
211.2
Alternative Names:
n-[2-(nitrooxy)ethyl]-3-pyridinecarboxamide, 2-nicotinamidoethyl nitrate, sg-75
- Data sheet: View or download
- MSDS: View or download
Product Description:
A SUR2B/Kir6.2 activator (EC50 = ~10 µM) and nitric oxide donor; selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM); activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 = 4.4 µM); decreases mean blood pressure, coronary resistance, and heart rate, as well as increases coronary sinus outflow, in dogs at 1 mg/kg i.v.; increases survival and decreases infarct size in a rabbit model of left coronary artery occlusion-induced myocardial ischemia-reperfusion injury
Storage Temperature:
-20°C
