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144598-75-4
≥98%
A crystalline solid
426.5
3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one, 9-hydroxy risperidone, ro76477
- Data sheet: View or download
- MSDS: View or download
An atypical antipsychotic; an inverse agonist of dopamine D2 and D3 receptors (IC50s = 1 and 0.9 nM, respectively) as well as an antagonist at these receptors (Kis = 0.4 and 0.1 nM, respectively); binds to α1- and α2-adrenergic receptors, histamine H1 receptors, and the 5-HT receptor subtypes 5-HT1A , 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 10.1, 80, 3.4, 480, 19, 1.21, and 48 nM, respectively); improves spatial working memory in a T-maze alternation task in a maternal immune activation mouse model of schizophrenia at 0.05 mg/kg per day; an active metabolite of risperidone
-20°C
