(±)-Thalidomide
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50-35-1
≥98%
A solid
258.2
2-(2,6-dioxo-3-piperidinyl)-1h-isoindole-1,3(2h)-dione, n-phthaloylglutamimide, nsc 527179, nsc 66847
- Data sheet: View or download
- MSDS: View or download
An immunomodulatory compound with diverse biological activities; prevents PMN chemotaxis at 1, 10, and 100 µg/ml; increases IL-2-induced proliferation and IFN-γ production in primary human T cells in vitro; enhances NK cell-mediated cytotoxicity in MM.1S multiple myeloma cells; reduces lung IL-6, TGF-β, VEGF, angiopoietin-1, angiopoietin-2, and collagen type Iα1 expression, inhibits pulmonary angiogenesis, and attenuates fibrosis in a mouse model of bleomycin-induced pulmonary fibrosis at 4 mg/animal; induces apoptosis in primary human embryonic fibroblasts (EC50 = 8.9 µM) and induces limb and eye defects in chicken embryos (EC50 = 50 µg/kg egg weight)
-20°C
