Methylprednisolone
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83-43-2
≥98%
A crystalline solid
374.5
11β,17,21-trihydroxy-6α-methyl-pregna-1,4-diene-3,20-dione, 6α-methylprednisolone, nsc 19987, u-7532
- Data sheet: View or download
- MSDS: View or download
A synthetic glucocorticoid, an agonist of glucorticoid and mineralocorticoid receptors, and an active metabolite of MPS; transactivates glucocorticoid and mineralocorticoid receptors in a reporter assay using CV-1 cells (EC50s = 2.92 and 2.31 nM for the human receptors, respectively); reduces endotoxin-induced complement activation in rabbits at 40 mg/kg; induces T cell apoptosis and reduces the number of T cell spinal cord infiltrates in a rat model of EAE when administered at a dose of 50 mg/kg; decreases the number of reactive spinal astrocytes, improves proprioceptive limb placing and coordination, and reduces spinal edema and the number of spinal necrotic cells in a rat model of spinal crush injury
-20°C
