£113.00
Estimated delivery Fri 10 May
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
63968-64-9
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
282.3
Alternative Names:
(3r,5as,6r,8as,9r,12s,12ar)-octahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin-10(3h)-one, nsc 369397
- Data sheet: View or download
- MSDS: View or download
Product Description:
An antimalarial agent with anticancer activity; an iron(II) oxide-reactive endoperoxide that generates ROS; reduces the growth of various P. falciparum strains in vitro (IC50s = 3.98-20.36 nM); reduces parasitemia in mice infected with P. falciparum (CD50 = 140 mg/kg); reduces P. berghei infection in mice (ED50 = 5.6 mg/kg per day); inhibits growth of SK-N-AS, BE(2)-C, SK-N-DZ, and SHEP1 neuroblastoma cells from 100-400 µM; suppresses BE(2)-C cell colony formation in a soft agar assay and reduces tumor growth in a BE(2)-C mouse xenograft model
Storage Temperature:
-20°C
