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SensoLyte® Rh110 Factor Xa Assay Kit *Fluorimetric* - ANA72207 - 1 kit - AnaSpec - assays & kits

SensoLyte® Rh110 Factor Xa Assay Kit *Fluorimetric*
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Size: 1 kit
£650.00
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Catalogue number:
ANA72207
Name:
SensoLyte® Rh110 Factor Xa Assay Kit *Fluorimetric*
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Factor Xa (FXa) is a serine endopeptidase composed of two disulfide-linked subunits. FXa leads to blood clot formation by converting prothrombin to thrombin through the prothrombinase complex. FXa is generated from zymogen Factor X via the intrinsic and extrinsic pathways and is the rate-limiting step in the propagation of thrombin generation. In the presence of Ca2+ ions, FXa forms prothrombinase with factor Va on the phospholipid membrane of the activated platelets. FXa has emerged as an attractive target for drug discovery for thromboembolic diseases. The SensoLyte® Rh110 Factor Xa Assay Kit provides a convenient assay for screening of FXa inhibitors or continuous assay ofEnzyme activity using a fluorogenic substrate. Upon FXa protease cleavage, this substrate generates the Rh110 (rhodamine 110) fluorophore which has a bright green fluorescence that can be detected at excitation/emission=490 nm/520 nm. The longer-wavelength spectra and higher extinction coefficient of the Rh110 provide greater sensitivity and less interference from other reaction components. Kit size: 100 assays

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Product Type:
Assays & Kits
UNSPSC Code:
41116012
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