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Indium (III) thiosemicarbazone 5b

Catalogue number:
CAY35601-25 mg
Supplier:
Size:
25 mg _$$_
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£691.00 Estimated delivery Fri 3 May
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:

2345755-20-4

Purity:

≥95%

Formulation:

A solid

Molecular Weight:

425

Alternative Names:

(oc-6-43)-dichloro[n,n-dimethyl-2-[(2-pyridinyl-κn)methylene]hydrazinecarbothioamide-κn2,κs]methoxy-indium

Product Description:

An anticancer agent; cytotoxic to A549, MCF-7 breast, MCF-7/DDP cisplatin-resistant breast, and Hl 7702 liver cancer cells (IC50s = 2.41, 1.97, 2.11 µM, and 8.95 µM, respectively); decreases PI3K, Akt, mTOR, P-gp, and GSH levels in MCF-7/DDP cells; reduces tumor weight and volume in an MCF-7/DDP mouse xenograft model at 2.5 µmol/kg; liposomes containing it induce apoptosis and pro-death autophagy in MCF-7/DDP cells, as well as reduce tumor volume and weight in an MCF-7/DDP mouse xenograft model

Storage Temperature:

-20°C

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