Sales & Support: +44 (0)1223 316 855


MCC950 (sodium salt)

Catalogue number:
CAY34762-10 mg
10 mg _$$_
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£147.00 Estimated delivery Fri 26 Apr
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:





A solid

Molecular Weight:


Alternative Names:

n-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide, monosodium salt, cp 456,773

Product Description:

An inhibitor of NLRP3 inflammasome activation; inhibits ATP-induced IL-1β release in LPS-primed mouse BMDMs (IC50 = 7.5 nM), as well as cytosolic LPS-induced IL-1β release in Pam3CSK4-primed mouse BMDMs at 0.1 and 1 µM; selective for NLRP3 over NLRC4 and AIM2 inflammasomes and does not inhibit LPS-induced NLRP3 priming in mouse BMDMs at 10 µM; reduces ox-LDL-induced increases in caspase-1 activity and inhibits pyroptosis in THP-1 macrophages at 1 µM; reduces myocardial fibrosis in mice following myocardial infarction induced by left coronary artery ligation at 10 mg/kg; improves forelimb grip strength and reduces spinal edema in a mouse model of spinal crush injury at 10 mg/kg

Storage Temperature:


Details Cat number & supplier Size Price
MCC950 CAY17510-1 mg · Cayman Chemical
CAY17510-1 mg
Cayman Chemical
1 mg £105.00
1 mg