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Akuammine

Catalogue number:
CAY35149-5 mg
Supplier:
Size:
5 mg _$$_
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£601.00 Estimated delivery Fri 3 May
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:

3512-87-6

Purity:

≥98%

Formulation:

A crystalline solid

Molecular Weight:

382.5

Alternative Names:

(2s,3e,7as,12as,12bs,15r)-3-ethylidene-1,3,4,6,7,12b-hexahydro-9-hydroxy-12-methyl-2h,12h-12a,2,7a-(epoxyethanylylidene)indolo[2,3-a]quinolizine-15-carboxylic acid, methyl ester, (-)-akuammine, vincamajoridine

Product Description:

An indole alkaloid with analgesic activity; selectively binds the µ- and κ-opioid receptors over the δ-opioid receptor (Kis = 0.3, 1.68, and 10.4 µM for the human receptors, respectively); inhibits forskolin-induced cAMP production in HEK293 cells expressing human µ- or κ-opioid receptors (IC50s = 2.6 and 0.073 µM, respectively); increases the latency to withdrawal in the tail-flick or hot plate test in mice at 60 mg/kg

Storage Temperature:

-20°C

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