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MF766

Catalogue number:
CAY36076-1 mg
Supplier:
Size:
1 mg _$$_
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£89.00 Estimated delivery Fri 3 May
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:

1050656-06-8

Purity:

≥95%

Formulation:

A solid

Molecular Weight:

478.5

Alternative Names:

4-[1-[[[1-[[4-(trifluoromethyl)phenyl]methyl]-1h-indol-7-yl]carbonyl]amino]cyclopropyl]-benzoic acid

Product Description:

An EP4 receptor antagonist (Ki = 0.23 nM); selective for EP4 over DP1 (Ki = 1,648 nM) as well as EP1, EP2, EP3, CRTH2/DP2, IP, TP, and FP recetors (Kis = >6,000 nM for all); inhibits PGE2-induced cAMP accumulation in HEK293 cells (IC50 = 1.3 nM); reverses PGE2-induced decreases in IFN-γ production in IL-2-stimulated primary human natural killer cells at 312.5 and 1,250 nM; reduces paw edema in a rat model of adjuvant-induced arthritis; inhibits tumor growth in a CT26 murine colon cancer model at 30 mg/kg

Storage Temperature:

-20°C

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