£472.00
Estimated delivery Fri 24 May
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
3432-99-3
Purity:
≥75% (mixture of diastereomers)
Formulation:
A solid
Molecular Weight:
457.4
Alternative Names:
n-[4-(3-amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9h)-yl)benzoyl]-l-glutamic acid, 5,10-methyl thf, 5,10-methylenetetrahydrofolic acid
- Data sheet: View or download
- MSDS: View or download
Product Description:
A reduced form of folate and cofactor for thymidylate synthetase; forms a ternary complex with thymidylate synthetase and FdUMP that inhibits thymidylate synthetase activity and DNA synthesis; has synergistic or additive cytotoxic effects against LS 174 or HT-29 human colon cancer cells, respectively, when used in combination with 5-fluorouracil; increases survival and reduces tumor growth in an HT-29 mouse xenograft model at 0.6 mg/animal when administered in combination with 5-fluorouracil
Storage Temperature:
-80°C