£43.00
Estimated delivery Tue 14 May
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1190217-35-6
Purity:
≥95%
Formulation:
A crystalline solid
Molecular Weight:
263.3
Alternative Names:
(2e)-2-[7-fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3h-indol-3-ylidene]-acetic acid
- Data sheet: View or download
- MSDS: View or download
Product Description:
A TRPA1 agonist; induces calcium influx in HEK293 cells expressing human, rat, or mouse TRPA1 (EC50s = 0.51, 0.54, and 0.5 µM, respectively) and stimulates 5-HT release from QGP-1 enterochromaffin cells that endogenously express TRPA1 (EC50 = 72.5 µM); reduces colonic transit time in clonidine- or loperamide-induced mouse models of constipation at 1 mg/kg; reduces the number of abdominal contractions induced by colorectal distension in mice at 0.3 mg/kg
Storage Temperature:
-20°C