£70.00
Estimated delivery Tue 14 May
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
4342-03-4
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
182.2
Alternative Names:
5-(3,3-dimethyl-1-triazen-1-yl)-1h-imidazole-4-carboxamide, nci c04717, nsc 45388
- Data sheet: View or download
- MSDS: View or download
Product Description:
A DNA alkylating prodrug; converted into a methyldiazonium cation that alkylates DNA at all phases of the cell cycle and induces apoptosis; inhibits the growth of B16/F1, A-875, and SK-MEL-5 melanoma and non-cancerous WI-38 lung fibroblast and L-02 hepatocyte cell lines (IC50s = 260, 287, 380, 526, and 367 µM, respectively); toxicity to 518A2 and SK-MEL-28 melanoma cell lines increases in a time-dependent manner (IC50s = 121 and >400, respectively, at 1 hour and 2.5 and 50 µM, respectively, at 96 hours); decreases tumor volume by 59.1% in a B16/F1 murine melanoma model in mice (70 mg/kg, once every 2 days)
Storage Temperature:
-20°C