Imisopasem Manganese
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218791-21-0
≥95%
A crystalline solid
483.4
(pb-7-11-2344′3′)-dichloro[(4ar,13ar,17ar,21ar)-1,2,3,4,4a,5,6,12,13,13a,14,15,16,17,17a,18,19,20,21,21a-eicosahydro-11,7-nitrilo-7h-dibenzo[b,h][1,4,7,10]tetraazacycloheptadecine-κn5,κn13,κn18,κn21,κn22]-manganese, m40403
- Data sheet: View or download
- MSDS: View or download
A SOD mimetic; catalyzes dismutation of the superoxide anion with a catalytic rate constant of >2 x 107 M-1s-1; reduces carrageenan-induced paw edema and inhibits increases in paw exudate levels of TNF-α, IL-1β, and LDH in rats at 1-10 mg/kg, i.v. bolus; inhibits increases in lung and ileum MPO levels, indicating reduced neutrophil infiltration, and increases in plasma MDA, TNF-α, and IL-1β levels in a rat model of ischemia-reperfusion injury and shock induced by SAO at 0.1, 0.3, and 1 mg/kg
-20°C