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GBT-440

Supplier:
Catalogue number:
B3031-25
Size:
25 mg
Product is available in:
  • UK
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£683.00 Estimated delivery Wed 23 Jun
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GTB-440 is a modulator of sickle hemoglobin S (HbS). It binds to the N‐terminal valine of one of the haemoglobin α chains and increases HbS affinity for oxygen. GBT440 dose‐dependently increases HbS affinity for oxygen (EC₅₀ = 8·2 µM) for purified HbS and (EC₅₀ = 415 µM) for whole blood from sickle cell disease (SCD) patients. It delays in vitro HbS polymerisation and prevents sickling of RBCs. In a murine model of SCD, GBT-440 (100 and 150 mg/kg for 9–12 d) increases the half‐life of RBCs, reduces reticulocyte counts and prevents ex vivo RBC sickling.

Product Type:

Biochemicals

CAS Number:

1446321-46-5

Storage Temp:

-20°C

Compound Purity:

≥98%

Molecular Weight:

337.37

UNSPSC Code:

12352200

GBT-440

GBT-440

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