246529-22-6
≥98%
702
(4R)-4-[(3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-3-(icosanoylamino)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid; 3beta-arachidylamido-7alpha,12alpha-dihydroxy-5beta-cholan-24-
- Data sheet: View or download
- MSDS: View or download
Aramchol is a conjugate of cholic acid and arachidic acid. It is a synthetic fatty-acid/bile-acid conjugate (FABAC). It significantly reduces hepatic fat content in a high fat diet animal model. It dissolves pre-existing cholesterol crystals in model bile solutions. It causes 70% to 83% inhibition of stearoyl coenzyme A desaturase 1 (SCD1) activity in vitro. Aramchol (0.5 mg or 1.0 mg/d) reduces the development of gallstones or cholesterol crystals in mice fed a lithogenic high-fat diet. It significantly reduces liver fat content in patients with nonalcoholic fatty liver disease.
-20°C
