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Anti-IL-17Rα (Brodalumab), Human IgG2 Antibody

Supplier:
Catalogue number:
A2155-100
Size:
100 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£581.00 Estimated delivery Wed 23 Jun
Shipping is calculated in checkout

The research-grade biosimilar is a recombinant, fully human IgG2 kappa monoclonal antibody that binds with a high affinity to the Interleukin-17 receptor α (IL-17Rα). IL-17R is a type I membrane glycoprotein that is ubiquitously expressed on cell surfaces and binds IL17α with low affinity. IL17α plays an important role in the pathogenesis of inflammatory and autoimmune diseases such as rheumatoid arthritis. The antibody binds to the IL-17Rα and inhibits IL-17 induced release of pro-inflammatory cytokines and chemokines such as NF-κB, IL-6, IL-8, COX-2, MMPs, and GM-CSF. The original drug received approval from the FDA to treat moderate-to-severe psoriasis

Product Type:

Antibodies

Species Reactivity:

Human

Storage Temp:

-80°C

Antibody Host:

Recombinant

Antibody Isotype:

Human IgG2, kappa

Formulation:

In PBS, pH 7.5

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

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