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Anti-IL-6 (Siltuximab), Chimeric Antibody

Supplier:
Catalogue number:
A2143-100
Size:
100 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£581.00 Estimated delivery Wed 23 Jun
Shipping is calculated in checkout

Siltuximab is a chimeric (human-murine) IgG1 kappa monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells. This antibody binds to and neutralises human IL-6, inhibits IL-6 binding to its receptor, and subsequent IL-6 signaling. Siltuximab was developed by Janssen Biotech and received FDA approval in 2014 to treat patients suffering from multicentric Castleman’s disease, but are negative for HIV and HHV-8. This monoclonal antibody has recently been investigated for the treatment of various forms of cancer such as metastatic renal cell cancer, ovarian cancer, and prostate cancer. Siltuximab is marketed under the brand name of SYLVANT™

Product Type:

Antibodies

Species Reactivity:

Human

Storage Temp:

-80°C

Antibody Host:

Human/Mouse chimeric

Antibody Isotype:

IgG1, kappa

Formulation:

In PBS, pH 7.5

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

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