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Sildenafil

Supplier:
Catalogue number:
CAY10008671-25 mg
Size:
25 mg
Product is available in:
  • UK
  • Ireland
  • Europe
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  • Rest of World
£81.00 Estimated delivery Fri 18 Jun
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A PDE5 inhibitor (IC50s = 3.6 and 3 nM for PDE5 activity in isolated rabbit platelets and human corpus cavernosum, respectively); selective for PDE5 over PDE1 and PDE3 (IC50s = 0.26 and 65 µM, respectively); reverses glucose-induced decreases in ANG1 expression and reduction of capillary-like tube formation by mouse dermal endothelial cells in vitro; increases the number of functional blood vessels and regional blood flow in the sciatic nerve in a db/db mouse model of diabetic peripheral neuropathy; increases ICP/MAP ratio in castrated rats at 20 mg/kg per day; reduces cardiac arrest and resuscitation-induced increases in angiotensin II ACE, ACE2, and various angiotensin receptors and increases survival in a porcine model of ischemia/reperfusion injury

Product Type:

Biochemicals

CAS Number:

139755-83-2

Alternative Names:

5-[2-ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7h-pyrazolo[4,3-d]pyrimidin-7-one

Storage Temp:

-20°C

Formulation:

A crystalline solid

Compound Purity:

≥98%

UNSPSC Code:

12352200

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