Cambridge Bioscience has a close collaboration with Research Donors, a London-based clinic, dedicated to the collection of human blood biospecimens for research purposes.
Our leukapheresis service provides researchers with fresh leukopaks containing 10 billion total nucleated cells on average from a single donor, with delivery available on the same or next day after collection (location dependent).
Collections are tailored to each researchers' specific needs, so the choice of volume, shipment temperature and blood group is yours. Leukopaks contain highly concentrated peripheral blood mononuclear cells (PBMC) which are ideal for applications including immunology and cell therapy (e.g. CAR-T) research, toxicology studies and high-throughput drug screening.
Research Donors is an HTA licensed, ISO 9001 2015 certified establishment with Research Ethics (REC) approval as a Research Tissue bank, as well as participating in the UK NEQAS QA scheme.
Benefits of using our leukapheresis service
• 10 billion total nucleated cells per donor on average
• Same day or overnight delivery available (location dependent)
• Specific donor criteria requests accommodated
• High-viability PBMC with minimal degradation
• Leukopak collections available 4 days per week
• Comprehensive donor information provided, including full blood counts
• HTA-licensed, ISO 9001 2015 certified and Research Ethics approved facility
• Samples fully consented including for genetic analysis, animal models and commercial research purposes
• Large donor pool
• Available in full, half or quarter bag sizes
• Donors pre-screened for HIV, HBV, HCV, Syphilis, HTLV I and HTLV II
With the wider use of cellular immune therapies, there is an increased demand from researchers for highly concentrated PBMC from a single individual. The traditional method of isolating PBMC from standard blood donations is limited by the maximum volume of blood that can be collected per donor (500 ml) and typically results in 1 to 2 million PMBC per ml of blood. Leukapheresis is the process by which a large number of total nucleated cells are separated from the blood of a single donor, resulting in a high concentration of PBMC, such as lymphocytes (T cells, B cells, and NK cells), monocytes and dendritic cells.
1. Whole blood is collected from the donor via intravenous tube in one arm
2. Whole blood passes through a Spectra Optia® apheresis machine, which separates white blood cells from the blood
3. The white blood cells are collected in a leukopak for storage
4. The unused blood components are safely returned to the donor via intravenous tube in the other arm
Contact our blood specialists
To request a quote or find out more, please contact our blood specialists.
These products are for research use only and not for any diagnostic or therapeutic use. It is your responsibility to ensure that you have necessary licensing and ethics approvals in place for the use and storage of any human tissue related material supplied by Cambridge Bioscience.
Spectra Optia is a registered trademark of Terumo BCT, Inc