Swift Biosciences

Swift Biosciences develop enabling technologies which push the limits and extend the applications of next-generation sequencing (NGS). They have developed unique intellectual property (IP) in the fields of ligation, amplification, purification and DNA repair.

Swift’s Adaptase technology allows for minimal adapter dimers with no need for adapter titration. Adaptase is single strand compatible and so maximises recovery of DNA from bisulphite-converted samples, or other damaged and fragmented DNA or RNA samples.

Using their technology, Swift Biosciences has developed DNA sequencing library kits for use with double-stranded DNA, single-stranded DNA and bisulphite-converted DNA. These kits enable the construction of libraries from difficult-to-use and previously limiting samples, such as FFPE and cfDNA. The products are platform agnostic and applicable across the three major NGS platforms: Illumina®, Ion Torrent™, and Pacific Biosciences®.

Swift’s library preparation kits allow the construction of targeted DNA sequencing libraries in a single tube, from minute amounts of DNA in less than 2 hours and their amplification technology enables the design of overlapping amplicons and offers full gene coverage.

Products fall into the following groups:

Epigenetics
Swift Biosciences offers fully optimised NGS library preparation solutions to study epigenetic modifications such as DNA methylation and histone post-translational modifications (PTMs).

Genotyping
To maximise data output from genotyping studies while reducing sequencing costs, Swift Biosciences has developed a comprehensive range of library kits.

Oncology/liquid biopsy
Swift Biosciences has developed a range of proprietary technologies to facilitate the generation of high-quality libraries from challenging samples such as FFPE tissues and liquid biopsy material.

Library normalisation
Designed to streamline library normalisation, Swift Biosciences’ Normalase Kit eliminates the need to dilute libraries of variable concentration before pooling and loading on sequencing platforms. By replacing conventional library amplification primers with Normalase primers, library pools of equivalent concentration are created for balanced sample representation. The Swift Normalase method is easily integrated into standard protocols and improves both turnaround time and accuracy by reducing the number of handling steps.

Accel-NGS 1S DNA library kit citations
Accel-NGS 2S DNA library kit citations
Accel-NGS Methyl-Seq DNA library kit citations

Cambridge Bioscience is pleased to supply Swift Biosciences products in the UK.

Illumina® is a registered trademark of Illumina, Inc.
Ion Torrent™ is a trademark of Thermo Fisher Scientific.
Pacific Biosciences® is a registered trademark of Pacific Biosciences.