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Dimebolin

Catalogue number:
CAY9000556-1 mg
Supplier:
Size:
1 mg _$$_
Product is available in:
  • UK
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£28.00 Estimated delivery Wed 31 Jul
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:

3613-73-8

Purity:

≥98%

Formulation:

A crystalline solid

Molecular Weight:

319.4

Alternative Names:

2,3,4,5-tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-1h-pyrido[4,3-b]indole, dimebon™, latrepirdine

Product Description:

A neuroprotective agent; binds to histamine H1 and H2 receptors (IC50s = 3.8 and 287 nM, respectively), as well as α1A-, α1B-, α1D-, and α2A-ARs, imidazoline I2 receptors, and 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 receptors (Kis = 8-313 nM); inhibits NMDA-evoked currents and voltage-gated calcium channels in mouse primary striatal neurons (IC50s = 10 and 50 µM, respectively); inhibits glutamate-induced apoptosis in primary striatal neurons derived from the YAC128 transgenic mouse model of Huntington’s disease at 50 µM; inhibits cell death induced by amyloid-β (25-35) in cerebellar granule cells at 25 µM; inhibits decreases TWAA acquisition in a rat model of AF64A-induced Alzheimer’s disease at 1 mg/kg

Storage Temperature:

-20°C

CAY9000556-1 mg: Dimebolin
CAY9000556-1 mg: Dimebolin
Details Cat number & supplier Size Price
Dimebolin (hydrochloride) CAY10011349-1 mg · Cayman Chemical
CAY10011349-1 mg
Cayman Chemical
1 mg £30.00
1 mg
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