Difenoconazole

A triazole antifungal; inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol; inhibits the growth of F. graminearum isolates in vitro (EC50s = 1.69-19.6 mg/L for mycelial growth); inhibits growth of A. sonali, F. fulva, B. cinerea, and R. solani (EC50s = 0.131, 0.069, 0.297, and 0.252 mg/L, respectively); reduces germtube growth of A. caricae (EC50 = 2 ppm); lethal to zebrafish embryos, larvae, and adults (LC50s = 2.34, 1.17, and 1.45 mg/L, respectively); induces pericardial and yolk sac edema in zebrafish embryos, body blackening and slowed heart rate in larvae, and decreased body weight and length in adults