LDN-193189 dihydrochloride
Catalogue number:
B2986-5
Supplier:
BioVision
Size:
5 mg _$$_
Product is available in:
N/A
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CAS Number:
1435934-00-1
Purity:
>98%
Molecular Weight:
479
Alternative Names:
4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline,dihydrochloride
- Data sheet: View or download
- MSDS: View or download
Product Description:
LDN-193189 inhibits transcriptional activity of the (Bone Morphogenetic Protein) BMP type I receptors known as activin receptor-like kinases (ALKs). It inhibits ALK2 and ALK3 with IC₅₀ values of 5 nM and 30 nM respectively and shows weaker effects on activin and the TGF-β type I receptors ALK4, ALK5 and ALK7. It inhibits phosphorylation of the BMP signaling effectors SMAD1, SMAD5 and SMAD8 with IC₅₀ value of 5 nM. LDN-193189 significantly reduces tumor growth in SCID mice bearing MDA-PCa-118b tumors.
Storage Temperature:
-20°C
