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CAS Number:
41179-33-3
Purity:
≥99%
Molecular Weight:
349
Alternative Names:
4-[4-(2-fluorophenyl)phenyl]-N-(4-hydroxyphenyl)butanamide; 2'-fluoro-N-(4-hydroxyphenyl)-[1,1'-biphenyl]-4-butanamide; Mitogen-activated protein kinase-activated protein kinase 2a Inhibitor; MK2a Inhibitor
- Data sheet: View or download
- MSDS: View or download
Product Description:
MK2a inhibitor is a substrate-selective inhibitor of p38α MAPK that selectively inhibits p38α-dependent phosphorylation of mitogen-activated protein kinase-activated protein kinase 2 (MK2a) with a K(i)(app) of 330 nM. It does not inhibit the phosphorylation of ATF-2 and MBP. It inhibits proliferation of U87, A172, and U251 glioblastoma cells with EC₅₀ values of 0.6-1 µM by inhibition of tubulin polymerization and induction of apoptosis.
Storage Temperature:
-20°C