Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognise the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralised bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1.
In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide