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Anti-Cathepsin S Antibody

Supplier:
Catalogue number:
A1618-100
Size:
100 µl
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£479.00 Estimated delivery Wed 28 Apr
Shipping is calculated in checkout

Cathepsin S (CTSS) is a lysosomal cysteine protease of the papain family and may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS is synthesised as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide, a propeptide of 99 aa, and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. The deduced amino acid sequence contains only one potential N-glycosylation site located in the propeptide. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicate that cathepsin S generates amyloid beta-peptide from amyloidogenic fragments of amyloid precursor protein (APP) in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease and Down Syndrome.

Product Type:

Antibodies

Species Reactivity:

Human, Mouse, Rat

Storage Temp:

-20°C

Antibody Host:

Rabbit

Antibody Isotype:

Rabbit IgG

Formulation:

In phosphate buffered saline , pH 7.4, 150mM, NaCl, 0.02% sodium azide and 50% glycerol.

Antibody Type:

Polyclonal

UNSPSC Code:

12352203

Anti-Cathepsin S Antibody

Anti-Cathepsin S Antibody