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Anti-Cathepsin S Antibody

Catalogue number:
100 µl
Product is available in:
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£479.00 Estimated delivery Wed 28 Apr
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Cathepsin S (CTSS) is a lysosomal cysteine protease of the papain family and may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS is synthesised as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide, a propeptide of 99 aa, and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. The deduced amino acid sequence contains only one potential N-glycosylation site located in the propeptide. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicate that cathepsin S generates amyloid beta-peptide from amyloidogenic fragments of amyloid precursor protein (APP) in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease and Down Syndrome.

Product Type:


Species Reactivity:

Human, Mouse, Rat

Storage Temp:


Antibody Host:


Antibody Isotype:

Rabbit IgG


In phosphate buffered saline , pH 7.4, 150mM, NaCl, 0.02% sodium azide and 50% glycerol.

Antibody Type:




Anti-Cathepsin S Antibody

Anti-Cathepsin S Antibody