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Human CellExp™ Her2 / ErbB2, Cynomolgus Recombinant

Supplier:
Catalogue number:
P1347-50
Size:
50 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£441.00 Estimated delivery Wed 28 Apr
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Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2, HER-2 /neu, NEU, NGL, TKR1 and c-erb B2, and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation.

Product Type:

Proteins and peptides

Alternative Names:

ERBB2, CD340, HER-2/neu, HER2, MLN19, NEU, NGL, TKR1

Storage Temp:

-20°C

Molecular Weight:

71.2

UNSPSC Code:

12352202

Human CellExp™ Her2 / ErbB2, Cynomolgus

Human CellExp™ Her2 / ErbB2, Cynomolgus Recombinant