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Anti-Cathepsin D Antibody

Supplier:
Catalogue number:
A1587-30T
Size:
30 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£114.00 Estimated delivery Wed 28 Apr
Shipping is calculated in checkout

Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesised as an inactive 52 kDa pro-enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment and an internal cleavage to generate the two-chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localisation signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, Cathepsin D is abnormally processed and is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitro evidence sµggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer.

Product Type:

Antibodies

Species Reactivity:

Human, Mouse

Storage Temp:

-20°C

Antibody Host:

Rabbit

Antibody Isotype:

Rabbit IgG

Formulation:

In PBS pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin

Antibody Type:

Polyclonal

UNSPSC Code:

12352203

Anti-Cathepsin D Antibody

Anti-Cathepsin D Antibody