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Anti-CPS1 Antibody (CPS1/1022)

Supplier:
Catalogue number:
A1579-100
Size:
100 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£505.00 Estimated delivery Wed 28 Apr
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This mAb recognizes a protein of 165 kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyses synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC occurs primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.

Product Type:

Antibodies

Species Reactivity:

Human, Dog

Storage Temp:

-20°C

Antibody Host:

Mouse

Antibody Isotype:

Mouse / IgG1

Formulation:

Supplied in 10 mM PBS with 0.05% BSA & 0.05% azide

Antibody Type:

Monoclonal

Clone Number:

CPS1/1022

UNSPSC Code:

12352203

Anti-CPS1 Antibody (CPS1/1022)

Anti-CPS1 Antibody (CPS1/1022)