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Anti-CD8A Antibody (C8/468)

Supplier:
Catalogue number:
A1570-100
Size:
100 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£505.00 Estimated delivery Wed 28 Apr
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CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 β chain (CD8 α/β) or as a homodimer (CD8 α/α). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

Product Type:

Antibodies

Species Reactivity:

Human

Storage Temp:

-20°C

Antibody Host:

Mouse

Antibody Isotype:

Mouse / IgG1, kappa

Formulation:

Supplied in 10 mM PBS with 0.05% BSA & 0.05% azide

Antibody Type:

Monoclonal

Clone Number:

C8/468

UNSPSC Code:

12352203

Anti-CD8A Antibody (C8/468)

Anti-CD8A Antibody (C8/468)