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CAS Number:
906673-24-3
Purity:
≥98% by HPLC
Molecular Weight:
251
Alternative Names:
4-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)oxy)benzonitrile; Crisaborole
- Data sheet: View or download
- MSDS: View or download
Product Description:
AN-2728 is a boron-based, topical anti-inflammatory agent that acts as a phosphodiesterase 4 (PDE4) inhibitor (IC₅₀ = 0.11 µM). It is less potent against PDE1A, PDE3A, and PDE7A (IC₅₀s = 6.12, 6.41, and 0.73 µM, respectively). AN-2728 suppresses the release of the proinflammatory cytokines TNF-α, IL-2, INF-γ, IL-5, and IL-10 with IC₅₀ values of 0.50, 0.59, 0.72, 2.25, and 2.58 µM, respectively.
Storage Temperature:
-20°C
