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CK-666 is a potent, selective and reversible inhibitor of ARP2/3 complex (actin related proteins 2 and 3) with an IC₅₀ = 4 µM for human ARP2/3. Blocks actin nucleation and radically alters lamellipodial actin architecture, suspended cell shape and the cell spreading process. CK-666 attenuates BBB dysfunction induced by methamphetamine. A key new tool for studying actin assembly and the diverse range of actin-related processes in normal and pathophysiology.
Product Type:
Biochemicals
CAS Number:
442633-00-3
Storage Temp:
-20°C
Compound Purity:
≥98% by TLC
Molecular Weight:
296.3
UNSPSC Code:
12352200
