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LOXO-195

Catalogue number:
Supplier:
BioVision
Size:
1 mg _$$_
Product is available in:
  • UK
  • Ireland
  • Europe
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  • Rest of World
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CAS Number:

2097002-61-2

Purity:

≥98% by HPLC

Molecular Weight:

380

Alternative Names:

(13E,14E,22R,6R)-35-fluoro-6-methyl-7-aza-1(5,3)-pyrazolo[1,5-a]pyrimidina-3(3,2)-pyridina-2(1,2)-pyrrolidinacyclooctaphan-8-one

Product Description:

LOXO-195 is a potent and selective TRK (tropomyosin-related-kinase) inhibitor, with potential anticancer activity. LOXO-195 specifically targets and binds to TRK, including the fusion proteins containing sequences from neurotrophic tyrosine receptor kinase (NTRK) types 1 (NTRK1), 2 (NTRK2), and 3 (NTRK3). This prevents neurotrophin-TRK interaction and TRK activation, which results in both the induction of cellular apoptosis and the inhibition of cell growth in tumors that overexpress TRK and/or express NTRK fusion proteins.

Storage Temperature:

-20°C

LOXO-195
LOXO-195