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CAS Number:
198474-05-4
Purity:
≥98% by HPLC
Molecular Weight:
232
Alternative Names:
3‑(5-Fluoro‑1H‑indol-3-yl)pyrrolidine-2,5-dione; EOS 200271
- Data sheet: View or download
- MSDS: View or download
Product Description:
PF-06840003 is a highly selective orally bioavailable indoleamine 2,3-dioxygenase -1 (IDO-1) inhibitor (IC₅₀ = 0.15 µM for human enzyme). It inhibits IDO-1-mediated production of kynurenine induced by IFN-γ in HeLa cells (IC₅₀ = 1.8 µM) and by LPS and IFN-γ in THP-1 cells and human-derived whole blood ex vivo (IC₅₀s = 1.7 and 4.7 µM, respectively).
Storage Temperature:
-20°C
