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PF-06840003 is a highly selective orally bioavailable indoleamine 2,3-dioxygenase -1 (IDO-1) inhibitor (IC₅₀ = 0.15 µM for human enzyme). It inhibits IDO-1-mediated production of kynurenine induced by IFN-γ in HeLa cells (IC₅₀ = 1.8 µM) and by LPS and IFN-γ in THP-1 cells and human-derived whole blood ex vivo (IC₅₀s = 1.7 and 4.7 µM, respectively).
Product Type:
Biochemicals
CAS Number:
198474-05-4
Storage Temp:
-20°C
Compound Purity:
≥98% by HPLC
Molecular Weight:
232.21
UNSPSC Code:
12352200
