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IACS-010759 is a potent and selective Oxidative Phosphorylation Inhibitor (IC₅₀ < 10 nM) with potential antineoplastic activity. IACS-010759 robustly inhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS, likely owing to a combination of energy depletion and reduced aspartate production that leads to impaired nucleotide biosynthesis.
Product Type:
Biochemicals
CAS Number:
1570496-34-2
Storage Temp:
-20°C
Compound Purity:
≥98% by HPLC
Molecular Weight:
562.57
UNSPSC Code:
12352200
