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CAS Number:
127373-66-4
Purity:
≥97% by HPLC
Molecular Weight:
434
Alternative Names:
2-(2-(4-(pivaloyloxy)phenylsulfonamido)benzamido)acetic acid; ONO-5046
- Data sheet: View or download
- MSDS: View or download
Product Description:
Sivelestat (ONO-5046) is a potent neutrophil elastase inhibitor. It acts as a substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC₅₀ = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase). Sivelestat displays >100-fold greater selectivity over pancreatic elastase (IC₅₀ = 5.6 µM). It does not inhibit trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G even at concentrations as high as 100 µM.
Storage Temperature:
-20°C
