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WT-161

Catalogue number:
Supplier:
BioVision
Size:
5 mg _$$_
Product is available in:
  • UK
  • Ireland
  • Europe
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  • Rest of World
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CAS Number:

1206731-57-8

Purity:

≥98% by HPLC

Molecular Weight:

458

Alternative Names:

(E)-8-(2-(4-(Diphenylamino)benzylidene)hydrazinyl)-N-hydroxy-8-oxooctanamide

Product Description:

WT-161 is a potent, selective, and bioavailable HDAC6 (histone deacetylase-6) inhibitor (IC₅₀ 0.40 nM). It is selective for HDAC6 over HDAC3 (IC₅₀ = 51.61 nM) and induces α-tubulin acetylation, an HDAC6-dependent process, with minimal effect on global lysine acetylation. WT161 inhibits growth of patient-derived multiple myeloma cell lines with IC₅₀ values ranging from 1.5 to 4.7 µM. WT161 enhances the cytotoxicity of bortezomib (Cat. No. 1846) and carfilzomib (Cat. No. 2385) against patient-derived multiple myeloma cells.

Storage Temperature:

-20°C

WT-161
WT-161